Hans Schmitthenner
Research Faculty
School of Chemistry and Materials Science
College of Science
Hans Schmitthenner
Research Faculty
School of Chemistry and Materials Science
College of Science
Education
BS, Massachusetts Institute of Technology; Ph.D., Pennsylvania State University
Bio
For more information please visit the Schmitthenner Research Group website.
Areas of Expertise
Molecular Imaging
Organic Synthesis
Medicinal Chemistry
Organometallic Chemistry Instrumental Analysis
HPLC-mass Spectrometry
Select Scholarship
Peer Reviewed/Juried Poster Presentation or Conference Paper
Jones, Kelsea, et al. "Practical Modular Synthesis of Targeted Imaging Agents for MRI, PET and PET-MRI." Proceedings of the MEDI 437 256th ACS Meeting, Boston, MA 2018. Ed. ACS. Boston, MA: ACS.
Published Conference Proceedings
Schmitthenner, Hans F, et al. "Modular Synthesis of Peptide-based Single and Multimodal Targeted Molecular Imaging Agents." Proceedings of the MEDI 204., 56th ACS National Meeting, Boston, MA(2019). Ed. ACS. Boston, MA: ACS, 2018. Web.
External Scholarly Fellowships/National Review Committee
6/1/2018 - 5/31/2021
NIH - NCI
Amount: $ 474,279
NIH - NCI
Amount: $ 474,279
9/1/2014 - 5/30/2018
NIH-NCI
Amount: $ 440,000
NIH-NCI
Amount: $ 440,000
Journal Paper
Schmitthenner, Hans F., et al. "Photoacoustic Imaging with an Acoustic Lens Detects Prostate Cancer Cells Labeled with PSMA-Targeting Near-Infrared Dye-Conjugates." Journal of Biomedical Optics 66019. 21. 6 (2016): 66019--66023. Print.
Orton, S.P., et al. "Broad Based Tissue Uptake of Polycationic Near-infrared Polymeric Nanoparticles in Living Mice." J Biomed Nanotechnol. 2013 Jan;9(1):77-85 9. 1 (2013): 77-85. Print.
Provisional Patent
Schmitthenner, Hans F., et al. "Loaded Latex Optical Molecular Imaging Probes Containing Lipophilic Large Stokes Shift Dyes." Patent US 8,906,354 B2. 12 Dec. 2014.
Schmitthenner, Hans F, et al. "Modular Imaging Agents Containing Amino Acids and Peptides." Patent 14/449,943. 1 Aug. 2014.
Currently Teaching
CHEM-301
Undergraduate Teaching Experience
1 - 3 Credits
This course allows students to assist in a class or laboratory for which they have previously earned credit. The student will assist the instructor in the operation of the course. Assistance by the student may include fielding questions, helping in workshops, and assisting in review sessions. In the case of labs, students may also be asked to help with supervising safety practices, waste manifestation, and instrumentation.
CHEM-493
Chemistry Research
1 - 3 Credits
This course is a faculty-directed student project or research in chemistry that could be considered of an original nature.
CHEM-495
Advanced Chemistry Research
1 - 3 Credits
This course is a faculty-directed student project or research involving laboratory work, computer modeling, or theoretical calculations that could be considered of an original nature. The level of study is appropriate for students in their final two years of study.
CHEM-790
Research & Thesis
1 - 6 Credits
Dissertation research by the candidate for an appropriate topic as arranged between the candidate and the research advisor.
CHEM-791
Continuation of Thesis
0 Credits
Continuation of Thesis
CHMA-650
Chemical Separations and Mass Spectrometry
3 Credits
This course will teach state of the art chemical separations and methods which are coupled to mass spectroscopy for the modern analysis of pharmaceutical and biotechnology samples in industrial and academic laboratories. These include gas chromatography (GC, GC-MS), high performance liquid chromatography (HPLC, LC-MS), solid phase extraction (SPE and SPME), size exclusion/gel permeation (SEC, GPC), and ion exchange chromatography (IXC). Aspects of mass spectroscopy including ionization methods of electron impact (EI), chemical ionization (CI), positive and negative electrospray (ES+, ES-), APCI, and MALDI and techniques involving single and multiple ion/reaction methods (SIM, SRM, MRM) will be included. The separation and analysis of peptides, proteins and pharmaceuticals by LC and LC-MS will be a major focus. Isolation of drug metabolites from serum by SPE followed by HPLC analysis or using size exclusion chromatography to separate biomolecules, or labeling a peptide with a near infrared (NIR) dye are examples of important skills that are learned.