This course provides students with an overview of clinical epidemiological concepts from which infectious and non-infectious diseases manifest in acute and chronic settings. This course will also build on the knowledge of statistics and provide students with an introduction to research methodology and design. The course design will enable the PA student to read and interpret medical literature and evaluate the findings. The course will introduce different research methods and outcomes assessment of Evidence-Based Medicine (EBM). The course will require the physician assistant student to create a formal written graduate research proposal, which will culminate with a graduate project in the fifth year of the PA Program. Projects may be in the form of: clinical practice essay, PA curriculum development, medically-related community service project, in-depth medical case review, meta-analysis of specific disease/syndrome, or original medical research