Funding Opportunities

Notice of Special Interest (NOSI): Improving Adherence to Treatment and Prevention Regimens and Maintenance of Health Behaviors to Promote Health

https://grants.nih.gov/grants/guide/notice-files/NOT-OD-24-146.html

Purpose

This Notice of Special Interest (NOSI) is being re-issued by the NIH Adherence Network through the Office of Behavioral and Social Sciences Research (OBSSR), with participation from multiple NIH Institutes, Centers, and Offices. This NOSI calls for research grant applications that address adherence to recommended treatment and prevention regimens or maintenance of behaviors to promote positive health outcomes (collectively referred to as health behaviors). Applications may address health behavior initiation, execution, and/or persistence through mechanistic studies, efficacy trials, or implementation research. Descriptive studies and intervention research may address relevant determinants at one or more levels of ecologic influence, including the individual, caregiver/family, provider, healthcare system, and community levels. Approaches designed to reduce health disparities and improve equitable health outcomes are strongly encouraged.

Due Dates: Various deadlines from 7/15/24 to 7/14/27

NIH Notice of Special Interest (NOSI): Validation of Digital Health and Artificial Intelligence/Machine Learning Tools for Improved Assessment in Biomedical and Behavioral Research

https://grants.nih.gov/grants/guide/notice-files/NOT-CA-24-031.html

Purpose:

The purpose of this Notice of Special Interest (NOSI) is to encourage grant applications to support the evaluation of the utility and validity of digital health and artificial intelligence/machine learning (AI/ML) tools and technologies in biomedical and behavioral research. The intent is to support the addition of new measurement modalities to evaluate existing and recently developed but not yet validated digital health and AI tools such as sensor technologies, smartphone applications, software as a medical device (SaMD), and AI/ML algorithms.

Research Objectives:

Research supported by this NOSI is expected to provide support for analytical and/or clinical validation of recently developed digital health and AI/ML technologies. Digital health and AI/ML technologies are defined broadly to include any health technology leveraging mobile health, health information technology, wearable devices, sensors, telehealth and telemedicine, internet of things (IoT), SaMD and/or related AI/ML algorithms and tools to monitor and manage health across the life course. As noted previously, the purpose of this NOSI is not to support the development of new tools or technologies.

Applicants should clearly justify the importance and implications of validating digital health and AI/ML tools and technologies. Studies should apply rigorous research methods to evaluate the analytical and/or clinical validity of any proposed digital health and AI/ML applications including the use of gold-standard comparators. Projects that validate digital health or AI/ML tools for a new context of use, including another disease area or specific populations (e.g., low income, minority group), and research projects that evaluate the reliability of the tool and its sensitivity are encouraged.

Studies proposing secondary analysis should address the sufficiency of existing datasets to validate technologies and deepen the evidence base of digital health and AI/ML applications while also addressing potential bias, including plans for risk mitigation that ensure safety, privacy, and effectiveness among diverse individuals and populations.  For Food and Drug Administration (FDA) regulated devices, activities included under this notice should follow FDA guidance and support appropriate activities leading to a future marketing submission to the FDA.

Investigators must carefully review the specific research interests of NIH Institutes and Centers (ICs) that are participating in this NOSI.

NIH Notice of Special Interest: Women’s Health Research

https://grants.nih.gov/grants/guide/notice-files/NOT-OD-24-079.html

In alignment with the White House Initiative on Women’s Health Research, the National Institutes of Health (NIH) is issuing this Notice of Special Interest to highlight interest in receiving research applications focused on diseases and health conditions that predominantly affect women (e.g., autoimmune diseases; depressive disorders, Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD), gender-based-violence), present and progress differently in women (e.g., cardiovascular disease; HIV; reproductive aging and its implications), or are female-specific (e.g., uterine fibroids; endometriosis; menopause).

For consideration under this NOSI, applications must have a central focus on the health of women, as demonstrated through specific aims that EITHER explicitly address a particular condition in women OR focus on one of the high priority topics below. In either approach, intersectional and/or multidimensional approaches that consider the health of women in context (e.g., projects accounting for social and structural variables—including race, ethnicity, socioeconomic status , and State and Federal policies— that affect women’s health) are strongly encouraged. For consideration under this NOSI, projects are not required to exclusively focus on women. However, studies that include more than one sex or gender should be designed and powered to make generalizable conclusions about women and enable sex or gender difference comparison.

Please view the NOSI NOT-OD-24-079 for a list of participating ICs and potential topics of interest.

Dear Colleague Letter: Advancing Research at the intersection of Biology and Artificial Intelligence (AI)/Machine Learning (ML)

https://www.nsf.gov/pubs/2024/nsf24131/nsf24131.jsp?WT.mc_ev=click&WT.mc_id=&utm_medium=email&utm_source=govdelivery

The U.S. National Science Foundation’s (NSF) Directorate for Biological Sciences (BIO) encourages the submission of proposals that advance biological research using Artificial Intelligence/Machine Learning (AI/ML) or AI/ML methods using biological data and systems.

To tackle grand challenge problems across the biological sciences, researchers increasingly are turning to the development and adoption of AI/ML methods. AI/ML includes any computational tool that mimics intelligence and the ability to learn from data to derive inferences. These methods are powerful tools for analyzing, synthesizing, and integrating large and complex datasets, developing predictive models, and designing and deploying bio-inspired innovations. Unique aspects of information processing in biological systems and the complexity of biological data can also inform and inspire new developments in AI/ML. In addition, AI-enabled research requires a trained workforce prepared to use, develop, and validate appropriate AI/ML approaches and supporting technologies tailored for biological systems.

To promote research that benefits from AI/ML and reduces barriers to its use in the biological sciences, BIO welcomes proposals that incorporate or advance AI/ML approaches across the research supported in all the Divisions of the BIO Directorate. Proposals in response to this DCL must advance one or more goals represented by NSF biological sciences programs through incorporating or developing AI/ML approaches. Proposers are encouraged to include partnerships between biologists and experts in AI/ML from academia, industry, or other organizations.

NSF Dear Colleague Letter: Funding Opportunities for Science and Engineering Research with Impact on Women's Health

https://www.nsf.gov/pubs/2024/nsf24068/nsf24068.jsp?WT.mc_ev=click&WT.mc_id=&utm_medium=email&utm_source=govdelivery 

With this Dear Colleague Letter (DCL), in response to the White House Initiative on Women's Health Research, the U.S. National Science Foundation (NSF) encourages the submission of research and education proposals related to women's health. Despite making up more than half of the population, women are historically understudied and underrepresented in health research. The historical exclusion of women from scientific and biomedical research studies, combined with the undervaluation of research that advances knowledge on conditions that uniquely, differentially, or disproportionately affect women, has resulted in significant knowledge and health gaps. Addressing these research gaps will ultimately advance the health, prosperity, and welfare of all.

NSF continues to support fundamental science and engineering research with implications for women's health. This DCL reaffirms NSF's commitment to fund discovery, innovation, and research translation on topics of relevance to women's health, from the molecular to the ecosystem level, including input from the full range of science, engineering, and education that NSF supports. Pioneering the next generation of discoveries in women's health will require a sustained effort focusing on the socioeconomic impact of women's health, breaking down disciplinary boundaries in carrying out the necessary research to advance understanding of relevant questions, and building a diverse STEM workforce committed to advancing women's health and the health of a citizens.

Please view the DCL NSF 24-068 for a list of potential topics related to women’s health.

Dear College Letter: Funding Opportunities for Engineering Research in Artificial Intelligence

NSF 24-039

Program Synopsis: 

With this Dear Colleague Letter, the U.S. National Science Foundation (NSF) Directorate for Engineering (ENG) encourages the submission of research and education proposals related to Artificial Intelligence as an Emerging Industry. Artificial intelligence (AI) is advancing rapidly and is increasingly demonstrating its potential to significantly transform our lives. NSF and the Engineering Directorate have a long and rich history of supporting AI research, setting the stage for today’s widespread use of AI technologies in a range of sectors, from commerce to healthcare to transportation. NSF’s AI portfolio spans AI theory, algorithms, robotics, human-AI interaction, and advanced cyberinfrastructure for AI, as well as use-inspired research in neuroscience, design and performance of engineered civil infrastructure systems, electric power grid, intelligent integrated manufacturing systems, intelligent transportation, robotics, and many other areas.

Deadline: For consideration during fiscal year 2024, proposals to programs without deadlines should be submitted by April 30, 2024; proposals submitted later will be considered for fiscal year 2025.

Dear Colleague Letter: Funding Opportunities for Engineering Research in Biotechnology

NSF 24-040

Synopsis of Program: 

With this Dear Colleague Letter, the U.S. National Science Foundation (NSF) Directorate for Engineering (ENG) encourages the submission of research and education proposals related to Biotechnology as an Emerging Industry. The U.S. is a world leader in biotechnology, a field that comprises the data, tools, research infrastructure, workforce capacity, and innovations that enable the discovery, utilization, and reprogramming of living organisms, their constituent components, and their biologically related processes. Advances supported by NSF and the Engineering Directorate include genome sequencing, editing, and synthesis; synthetic and engineered biology; imaging and biosensing; and tissue engineering and biomanufacturing. These capabilities also provide solutions to societal challenges, such as climate change and infectious disease, and provide the foundational and use-inspired research that will lead to the creation of goods and services that contribute to agriculture, health, security, manufacturing, energy, and environmental needs of the nation.

Deadline: For consideration during fiscal year 2024, proposals to programs without deadlines should be submitted by April 30, 2024; proposals submitted later will be considered for fiscal year 2025.

NIH Bioengineering Partnerships with Industry

https://grants.nih.gov/grants/guide/pa-files/PAR-24-325.html

Funding Opportunity Purpose:

This Funding Opportunity Announcement (FOA) solicits applications from research partnerships formed by academic and industrial investigators to accelerate the development and adoption of promising bioengineering tools and technologies that can address important biomedical problems. The objectives are to establish these tools and technologies as robust, well-characterized solutions that fulfill an unmet need and are capable of enhancing our understanding of life science processes or the practice of medicine. Awards will focus on supporting multidisciplinary teams that apply an integrative, quantitative bioengineering approach to developing technologies. The goal of the program is to support technological innovations that deliver new capabilities which can realize meaningful solutions within 5 – 10 years.

Funding Opportunity Goal(s):

To support hypothesis-, design-, technology-, or device-driven research related to the discovery, design, development, validation, and application of technologies for biomedical imaging and bioengineering. The program includes biomaterials (biomimetics, bioprocessing, organogenesis, rehabilitation, tissue engineering, implant science, material science, interface science, physics and stress engineering, technology assessment of materials/devices), biosensors/biotransducers (technology development, technology assessment, development of algorithms, telemetry), nanotechnology (nanoscience, biomimetics, drug delivery systems, drug bioavailability, microarray/combinatorial technology, genetic engineering, computer science, technology assessment), bioinformatics (computer science, information science, mathematics, biomechanics, computational modeling and simulation, remote diagnosis and therapy), imaging device development, biomedical imaging technology development, image exploitation, contrast agents, informatics and computer sciences related to imaging, molecular and cellular imaging, bioelectrics/biomagnetics, organ and whole body imaging, screening for diseases and disorders, and imaging technology assessment and surgery (technique development and technology development).

Upcoming Deadlines: Jan 28, 2025; May 28, 2025

*Letter of Intent due Dec 28, 2024; April 28, 2025

PCORI

PCORI Funding Announcements

Synopsis of Program: 

These PFAs seek to fund studies addressing patient-centered comparative clinical effectiveness research (CER), studies addressing high-priority methodological gaps in patient-centered CER or studies that build an evidence base on engagement in research. Areas of interest include managing pain, improving mental and behavioral health, phased large awards for comparative effectiveness research, broad pragmatic studies, advancing the science of engagement in research,  and improving methods for conducting patient-centered comparative clinical effectiveness research.

Deadline: Town halls will be held for the different funding opportunities in early December, with LOIs due on Jan 14, 2025 and applications due May 6, 2025.

ACED: Accelerating Computing-Enabled Scientific Discovery (ACED)

https://new.nsf.gov/funding/opportunities/aced-accelerating-computing-enabled-scientific?utm_medium=email&utm_source=govdelivery

Synopsis

The ACED program seeks to harness computing to accelerate scientific discovery, while driving new computing advancements. The intent is to catalyze advancements on both sides of a virtuous cycle that: (a) benefit scientific disciplines through computational technologies and (b) foster novel computing technologies that will enable advances beyond the specific use cases or domains originally targeted. The program seeks continuous collaborations between at least two groups of researchers. One group is expected to consist of researchers in computing, which, for the purposes of this solicitation are those disciplines that are supported by the Core Programs of National Science Foundation’s (NSF) Computer and Information Science and Engineering (CISE) directorate. The other group of researchers are expected to represent another scientific or engineering discipline, which, for the purposes of this solicitation, are defined as those supported within existing programs of the following NSF directorates: Biological Sciences, Engineering, or Mathematical and Physical Sciences.

The ACED program solicits proposals in two tracks: 

Track I: Emerging Ideas Proposals: This track is intended to support speculative multidisciplinary projects that explore bold new research directions. The goal of these projects should be to obtain preliminary results, refine the overall research plan based on these results, and garner insights into whether these advances generalize beyond the targeted use case or domain. Projects are limited to $500,000 in total budget, with durations of up to 18-24 months. Proposals accepted in 2024 Deadline Date.

Track II: Discovery Proposals: The objective of this track is to support transformative interdisciplinary research that will significantly advance both computing and the scientific discipline(s) to be studied. Proposals should clearly identify the scientific problem(s) to be addressed; the specific computing techniques to be developed; and be supported by preliminary collaborations and/or results that demonstrate the potential of the proposed ideas. Projects are limited to $750,000 per year for a duration of up to 4 years for a total budget of up to $3,000,000.  Proposals accepted in 2025-2026 Deadline Dates.

Application Deadlines: January 14, 2025 (Track II only)

Examining the Impact of Artificial Intelligence (AI) on Healthcare Safety (R18) 

https://grants.nih.gov/grants/guide/pa-files/PA-24-261.html

Funding Opportunity Purpose: The purpose of this NOFO is to invite grant applications that support healthcare safety by determining (1) whether and how certain breakthrough uses of Artificial Intelligence (AI) systems can affect patient safety; and (2) how AI systems can be safely implemented and used. AI has the potential to improve the safety, effectiveness, efficiency, accessibility, and affordability of healthcare. However, as with most technologies, this potential must be balanced by identifying and mitigating potential risks for patient harm and user burden.

Application Deadline: January 25, 2025

Biomedical Research Facilities (C06 Clinical Trial Not Allowed)

https://grants.nih.gov/grants/guide/pa-files/PAR-25-061.html

Funding Opportunity Purpose

This Notice of Funding Opportunity (NOFO) invites applications from eligible academic and research institutions to apply for funding to modernize existing or construct new biomedical research facilities. Applications will be accepted from public and private nonprofit institutions of higher education, as well as from non-profit research organizations. Applications from both research-intensive institutions and Institutions of Emerging Excellence (IEE) in biomedical research from all geographic regions in the nation are strongly encouraged.

NIH recognizes the importance of all institutions of higher learning in contributing to the nation’s research capacity from either research-intensive or low-resourced institutions. The goal of this NOFO is to modernize biomedical research infrastructure to strengthen biomedical research programs. Each project is expected to produce substantial long-term improvements to the institutional research infrastructure. Intended projects are the construction or modernization of core facilities and the development of other shared research infrastructure serving an institution-wide research community with broad impact on biomedical research. 

Application Deadline: Jan 27, 2025 (Letter of Intent: Dec 16, 2024 – encouraged, but not required).

PHT180 faculty interested in applying should email limitedsubmissions@rit.edu for guidance and submit an abstract for internal competition. More information can be found here: https://www.rit.edu/srs/limited-submission.

NIH Notice of Special Interest (NOSI): Topics for Training Modules for Enhancing Biomedical Research Workforce Training – 2025

https://grants.nih.gov/grants/guide/notice-files/NOT-GM-24-039.html

Purpose:

The purpose of this Notice of Special Interest (NOSI) is to inform applicants of the topic areas for the 2025 application due date for PAR-24-040 “Modules for Enhancing Biomedical Research Workforce Training (R25 - Clinical Trial Not Allowed)”.

Applications must address one of the topics below. Only one topic may be addressed per application.

1. Improving Mentorship Experiences: Effective mentorship is critical to the development and retention of scientists and the advancement of research. Studies have shown that effective mentorship has positive effects on mentees, mentors and the overall research environment (for example, improved academic achievement, retention, and degree attainment, career satisfaction, career commitment, and integration of trainees from underrepresented groups (see, e.g., Notice of NIH's Interest in Diversity)  into the biomedical academic community; see National Academies of Sciences, Engineering, and Medicine 2019, The Science of Effective Mentorship in STEMM). Formal training and ongoing professional development in effective mentoring practices has been shown to improve the knowledge and skills of research mentors across career stages. However, the 2019 NASEM report highlights the need to address ineffective mentoring experiences due to a lack of structure and purpose, poor mentor matching and preparation, lack of leadership support, and low engagement and participation. NIGMS encourages applications for modules that address the barriers and challenges to effective mentorship. Potential topics may include but are not limited to general mentorship education for departments, divisions, colleges, etc., including how to address negative mentoring or ineffective mentorship methods; mentor education for the needs of a broad range of scholars to avoid ineffective mentoring; mentee education about how to guide their mentoring relationships and careers to mitigate ineffective mentoring, among others. 
2. Improving Mental Health and Well-Being through Organizational Change: Navigating the biomedical research training pathway can be overwhelming and lead to stress, anxiety, and self-doubt. Organizations are in a position to establish programs that support the mental and physical well-being of the biomedical research workforce. The U.S. Surgeon General’s Framework for Workplace Mental Health and Well-Being, intended to spark organizational dialogue and change in the workplace, establishes five essential components to help re-imagine workplaces as engines of well-being including: 1) protection from harm, 2) connection and community, 3) life-work harmony, 4) mattering at work, and 5) opportunity for growth. NIGMS encourages applications for the development and implementation of training modules that will effectively address one or more of these five essential components at different organizational levels, such as departments, divisions, offices, and laboratories and may span multiple career stages, from students to organizational leadership.
3. Addressing Equity in the Biomedical Research Enterprise: The scientific community has an increasing appreciation for the need to address equity across career stages in the biomedical research enterprise. Applications are encouraged to develop and implement  modules focused on addressing  disparities in recruitment, retention, and success of trainees and other researchers, and how to identify and eliminate barriers to participation to promote access, inclusion, equity, and accessibility in the biomedical research environment. Modules should focus on how to create research training environments optimized for productive learning and research - free from harassment, intimidation, and discrimination - where all participants feel safe and are treated in a respectful and supportive manner. Applications must specify the skills and knowledge that will be gained by the participants and how the module will help the participants address the practices and ways of thinking that contribute to broad participation in the biomedical enterprise.
4. Promoting Laboratory Safety in Research Environments: NIGMS will support the development of training modules that will help catalyze a strong culture of responsibility and obligation to maintain high standards for physical, chemical, and biological safety in research training environments. Specifically, environments in which physical, chemical, and biological safety is prioritized, and the core values and behaviors of leadership and the research and training communities emphasize safety over competing goals. Applications must specify the skills and knowledge that will be gained by the participants and how it will help the participants address physical, chemical, and biological safety in the research environment.
5. Strengthening Rigor, Reproducibility, and Transparency of Biomedical Research Techniques: Principles of rigorous biomedical research are cross-cutting concepts, processes, and practices that promote rigorous, transparent, and robust scientific experiments. These principles apply across a wide variety of scientific disciplines, techniques, and approaches. NIH defines scientific rigor as “the strict application of the scientific method to ensure robust and unbiased experimental design, methodology, analysis, interpretation and reporting of results". The proposed module should develop content that promotes rigorous, reproducible, and transparent execution of biomedical research techniques relevant to the NIGMS mission.  Approaches to proper controls, sample size, statistical analyses, transparent reporting, and evaluation of the effects of biological variables such as sex and age, among others, associated with each method should be discussed.
6. Enhancing Program Evaluation Capacity: NIGMS encourages applications for modules to enhance  the development of evaluation capacity at organizations with biomedical research training programs. The proposed modules should inform program directors and administrators about effective and practical approaches to evaluate biomedical research training programs. The modules are expected to be developed with input from a range of experts (for example, social scientists, statisticians, education professionals).

Application and Submission Information:

This Notice applies to the January 28, 2025 due date for the following NOFO:

•  PAR-24-040 - “Modules for Enhancing Biomedical Research Workforce Training (R25 - Clinical Trial Not Allowed)"

NIH Stephen I. Katz Early Stage Investigator Research Project Grant (R01)

PAR-24-075 (no clinical trial)

PAR-24-076 (with human subjects)

Purpose:  

The Stephen I. Katz Early Stage Investigator Research Project Grant supports an innovative project that represents a change in research direction for an early stage investigator (ESI) and for which no preliminary data exist. Applications submitted to this notice of funding opportunity (NOFO) must not include preliminary data. Applications must include a separate attachment describing the change in research direction. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

Deadlines: January 28, 2025

NIH Maximizing Investigators' Research Award (MIRA) for Early Stage Investigators (ESI) - R35

https://grants.nih.gov/grants/guide/pa-files/PAR-23-145.html

Purpose:

The NIGMS Maximizing Investigators' Research Award (MIRA) provides support for the NIGMS-relevant program of research in an investigator's laboratory. For this NOFO, the "program of research" is defined as a collection of projects in an investigator's laboratory that are within the mission of NIGMS. This NOFO allows applications from eligible Program Directors/Principal Investigators (PDs/PIs) who are NIH-defined Early Stage Investigators (ESIs) at the time of submission.

Overview of ESI MIRA:

An NIGMS ESI MIRA is intended to provide support for the NIGMS-related research program in an ESI's laboratory. NIGMS supports research on basic biological processes as well as translational and clinical research in certain areas. In addition to research designed to answer scientific questions and generate new ideas and hypotheses, the development of technology and computational approaches are supported. Within the scope of the MIRA, investigators will have the freedom to explore new avenues of inquiry that arise during the course of their research, as long as they remain within the mission of NIGMS. 

Research involving human subjects is permitted in the MIRA program. Clinical research must be completely within the context of the NIGMS clinical areas (anesthesiology, perioperative pain, clinical pharmacology, sepsis, injury and critical illness, wound healing, innate immunity and inflammation). Clinical research that involves recruitment of human subjects at more than one site, or the substantial financial support of multiple collaborators and subcontractors, is not allowed, because these fixed commitments are not consistent with the highly flexible nature of the MIRA program. Mechanistic clinical trials are permitted in MIRA when the mechanistic study is an essential part of the research program. Clinical trials that are designed to test safety and efficacy of interventions (Phase I, Phase II, Phase III) for the purpose of future clinical treatment and/or regulatory approval are not permitted in MIRA. Studies that propose clinical dissemination and implementation research, comparative effectiveness research, and/or pragmatic clinical trials are also not permitted.

MIRA may not be the best mechanism to support all kinds of research, even though the research may be within the NIGMS mission. Because the MIRA is expected to provide support for the research program of an independent investigator’s laboratory, PDs/PIs may find other grant programs better suited to research requiring financial support of collaborators and subcontractors.

Because the MIRA is intended to support a significant and ambitious program of research, the PD/PI is required to devote at least 51% of their total research effort to this award. See Section III.1 Eligible Individuals for more information about this requirement.

Application Deadlines: February 3, 2025

NIH Focused Technology Research and Development (R01 Clinical Trial Not Allowed)

https://grants.nih.gov/grants/guide/pa-files/PAR-25-203.html

Funding Opportunity Purpose

This Notice of Funding Opportunity (NOFO) supports projects relevant to the NIGMS mission that focus solely on the development of technologies with potential to enable acquisition of biomedical knowledge. Projects should be justified in terms of technical innovation and utility of such technical innovation for impacting future biomedical research. Outcomes or products of the proposed project should significantly advance the current state of the art and be sufficiently characterized for application in addressing a broad range of biomedical research questions. These outcomes may include, but are not limited to:

laboratory instruments and other devices,

algorithms and software,

chemical reagents and processes,

biological molecules or systems that have been modified by human intervention for use as research tools.

The goal of this NOFO is to support the development of technologies that have demonstrated proof-of-concept but must overcome significant technical hurdles to prototype development and tests of potential broad utility. As such, applications should not propose to test specific biological questions. Applications that do propose tests of specific biological questions are not responsive to this NOFO and will be administratively withdrawn without review. Applications with a focus on optimization, hardening, or obvious extrapolations of established technology will be a lower priority for funding.

Funding Opportunity Goal(s)

The National Institute of General Medical Sciences (NIGMS) supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. NIGMS also supports research in specific clinical areas that affect multiple organ systems: anesthesiology and peri-operative pain; clinical pharmacology ​common to multiple drugs and treatments; and injury, critical illness, sepsis, and wound healing.​ NIGMS-funded scientists investigate how living systems work at a range of levels—from molecules and cells to tissues and organs—in research organisms, humans, and populations. Additionally, to ensure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in supporting the training of the next generation of scientists, enhancing the diversity of the scientific workforce, and developing research capacity throughout the country.

Upcoming Due Dates: Feb 5, 2025; June 5, 2025; Oct 5, 2025

Research with Activities Related to Diversity (ReWARD) w R01 Clinical Trial Optional

https://grants.nih.gov/grants/guide/pa-files/PAR-25-117.html

Funding Opportunity Purpose:

The NIH Research With Activities Related to Diversity (ReWARD) Program's overarching goal is to enhance the breadth and geographical location of research and research-related activities supported by NIH. The ReWARD program provides support for the health-related research of scientists who are making a significant contribution to Diversity, Equity, Inclusion, and Accessibility (DEIA) and who have no current NIH research project grant funding. The ReWARD program provides funding for both the scientific research and the DEIA activities of investigators. The grant will support scientific research in areas related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) and DEIA activities focused on enhancing diversity in the biomedical research enterprise within the United States and territories.

Upcoming Deadlines: Feb 5, 2025; June 5, 2025; Oct 5, 2025

A Science of Science Approach to Analyzing and Innovating the Biomedical Research Enterprise (SoS:BIO)

https://www.nsf.gov/pubs/2023/nsf23569/nsf23569.pdf

Program Description:

Science of Science Approach to Analyzing and Innovating the Biomedical Research Enterprise (SoS:BIO) is a joint program between the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) and the Science of Science: Discovery, Communication, and Impact Program (SoS:DCI) of the National Science Foundation (NSF). SoS:BIO supports research that advances the scientific basis of science and innovation policy, with a focus on the biomedical sciences. Consistent with the SoS:DCI program, SoS:BIO will fund the development of models, analytical tools, data and metrics that can inform science policy and the development of the scientific enterprise. SoS:BIO welcomes individual and collaborative research projects and places a high priority on interdisciplinary research and on broadening participation.

Application Deadline: February 10, 2025

NIH Catalyze: Enabling Technologies and Transformative Platforms for HLBS Research (R33 - Clinical Trials Not Allowed)

https://grants.nih.gov/grants/guide/rfa-files/RFA-HL-26-016.html

Funding Opportunity Purpose

This Notice of Funding Opportunity (NOFO) solicits grant applications to further develop enabling technologies and transformative platforms to catalyze next-generation predictive, diagnostic and therapeutic products to address heart, lung, blood, and sleep (HLBS)-related disorders and diseases. This NOFO solicits R33 applications where major feasibility gaps for the enabling technology or transformative platform have already been overcome, as demonstrated with supportive preliminary data, but still requires further development and rigorous validation to encourage downstream demonstration, utilization and adoption. Well-suited applications must offer the potential to accelerate and/or transform the areas of early detection and screening, model development, clinical diagnosis, treatment, control, prevention or epidemiology, while addressing issues associated with HLBS-related diseases and disorders. Projects proposing application of existing technologies where the novelty resides in the biological or clinical target/question being pursued are not appropriate for this solicitation. Applications considered nonresponsive to the NOFO will not be reviewed.

This NOFO is part of a suite of Catalyze innovation grants to advance projects to the point where they can meet the entry criteria for the NHLBI Catalyze Product Definition or Preclinical NOFOs.

Funding Opportunity Goal(s)

To foster heart and vascular research in the basic, translational, clinical and population sciences, and to foster training to build talented young investigators in these areas, funded through competitive research training grants.

The Division of Lung Diseases supports research and research training on the causes, diagnosis, prevention, and treatment of lung diseases and sleep disorders. Research is funded through investigator-initiated and Institute-initiated grant programs and through contract programs in areas including asthma, bronchopulmonary dysplasia, chronic obstructive pulmonary disease, cystic fibrosis, respiratory neurobiology, sleep and circadian biology, sleep-disordered breathing, critical care and acute lung injury, developmental biology and pediatric pulmonary diseases, immunologic and fibrotic pulmonary disease, rare lung disorders, pulmonary vascular disease, and pulmonary complications of AIDS and tuberculosis. The Division is responsible for monitoring the latest research developments in the extramural scientific community as well as identifying research gaps and needs, obtaining advice from experts in the field, and implementing programs to address new opportunities.

The Division of Blood Diseases and Resources supports research and research training on the pathophysiology, diagnosis, treatment, and prevention of non-malignant blood diseases, including anemias, sickle cell disease, thalassemia; leukocyte biology, pre-malignant processes such as myelodysplasia and myeloproliferative disorders; hemophilia and other abnormalities of hemostasis and thrombosis; and immune dysfunction. Funding encompasses a broad spectrum of hematologic inquiry, ranging from stem cell biology to medical management of blood diseases and to assuring the adequacy and safety of the nation's blood supply. Programs also support the development of novel cell-based therapies to bring the expertise of transfusion medicine and stem cell technology to the repair and regeneration of human tissues and organs.

The National Center on Sleep Disorders Research (NCSDR) supports research and research training related to sleep disordered breathing, and the fundamental functions of sleep and circadian rhythms. The center also stewards several forums that facilitate the coordination of sleep research across NIH, other federal agencies and outside organizations, including the Sleep Disorders Research Advisory Board and an NIH-wide Sleep Research Coordinating Committee. The center also participates in the translation of new sleep research findings for dissemination to health care professionals and the public. 

Upcoming Deadlines: Feb 11, 2025; June 18, 2025; Oct 21, 2025

Mentored Research Scientist Development Award (K01)

Independent Clinical Trial Required: https://grants.nih.gov/grants/guide/pa-files/PA-24-175.html
Independent Clinical Trial Not Allowed: https://grants.nih.gov/grants/guide/pa-files/PA-24-176.html
Independent Basic Experimental Studies with Humans Required: https://grants.nih.gov/grants/guide/pa-files/PA-24-177.html

Funding Opportunity Purpose

The purpose of the NIH Mentored Research Scientist Development Award (K01) is to provide support and “protected time” (three to five years) for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. Although all of the participating NIH Institutes and Centers (ICs) use this support mechanism to support career development experiences that lead to research independence, some ICs use the K01 award for individuals who propose to train in a new field or for individuals who have had a hiatus in their research career because of illness or pressing family circumstances. 

Independent Scientist Award (K02)

Independent Clinical Trial Required: https://grants.nih.gov/grants/guide/pa-files/PA-24-178.html
Independent Clinical Trial Not Allowed: https://grants.nih.gov/grants/guide/pa-files/PA-24-179.html
Independent Basic Experimental Studies with Humans Required: https://grants.nih.gov/grants/guide/pa-files/PA-24-180.html

Funding Opportunity Purpose

The purpose of the NIH Independent Scientist Award (K02) is to foster the development of outstanding scientists and enable them to expand their potential to make significant contributions to their field of research. The K02 award provides three to five years of salary support and "protected time" for newly independent scientists who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers. Each independent scientist career award program must be tailored to meet the individual needs of the candidate. 

Mentored Clinical Scientist Research Career Development Award (K08)

Independent Clinical Trial Required: https://grants.nih.gov/grants/guide/pa-files/PA-24-181.html
Independent Clinical Trial Not Allowed: https://grants.nih.gov/grants/guide/pa-files/PA-24-182.html
Independent Basic Experimental Studies with Humans Required: https://grants.nih.gov/grants/guide/pa-files/PA-24-183.html

Funding Opportunity Purpose

The primary purpose of the NIH Mentored Clinical Scientist Research Career Development Awards (K08) program is to prepare qualified individuals for careers that have a significant impact on the health-related research needs of the Nation. This program represents the continuation of a long-standing NIH program that provides support and "protected time" to individuals with a clinical doctoral degree for an intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research.

Midcareer Investigator Award in Patient-Oriented Research (K24)

Independent Clinical Trial Required: https://grants.nih.gov/grants/guide/pa-files/PA-24-187.html
Independent Clinical Trial Not Allowed: https://grants.nih.gov/grants/guide/pa-files/PA-24-188.html
Independent Basic Experimental Studies with Humans Required: https://grants.nih.gov/grants/guide/pa-files/PA-24-189.html

Funding Opportunity Purpose

The purpose of the NIH Midcareer Investigator Award in Patient-Oriented Research (K24) is to provide support to mid-career health-professional doctorates for protected time to devote to patient-oriented research (POR) and to act as research mentors for junior clinical investigators pursuing POR research, such as clinical residents and junior clinical faculty. 

Mentored Quantitative Research Development Award (K25)

Independent Clinical Trial Required: https://grants.nih.gov/grants/guide/pa-files/PA-24-190.html
Independent Clinical Trial Not Allowed: https://grants.nih.gov/grants/guide/pa-files/PA-24-191.html
Independent Basic Experimental Studies with Humans Required: https://grants.nih.gov/grants/guide/pa-files/PA-24-192.html

Funding Opportunity Purpose

The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and "protected time" for a period of supervised study and research for productive professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research.

Application Deadline for all opportunities: February 12, 2025

Using Innovative Digital Healthcare Solutions to Improve Quality at the Point of Care (R21/R33 - Clinical Trial Optional)

https://grants.nih.gov/grants/guide/pa-files/PA-24-266.html

Funding Opportunity Purpose: This NOFO invites applications that propose research projects that test promising digital healthcare interventions used at the point of care and aimed at improving the quality of healthcare services delivery. This NOFO will use the Phased Innovation Award (R21/R33) mechanism to provide up to 2 years of R21 support for initial developmental activities, and up to 3 years of R33 support for expanded activities.

Next Application Deadline: February 16, 2025

NIH Technology Development Research for Establishing Feasibility and Proof of Concept (R21 - Clinical Trial Not Allowed)

https://grants.nih.gov/grants/guide/pa-files/PAR-25-202.html

Funding Opportunity Purpose

This Notice of Funding Opportunity (NOFO)supports exploratory research leading to proof of concept for the development of new technologies relevant to the NIGMS mission. Projects should entail a high degree of risk and/or novelty, and have a high future potential impact in biomedical research. Outcomes or products of the proposed project, which should significantly advance the current state of the art, may include, but are not limited to:

laboratory instruments and other devices,

algorithms and software,

chemical reagents and processes,

biological molecules or systems that have been modified by human intervention for use as research tools. 

This NOFO does not support technology development that is narrowly focused on addressing specific biological questions or that re-purposes existing technologies for new uses. Rather, applications should propose development of new tools that can potentially benefit a broad spectrum of biomedical research. Moreover, feasibility of the proposed technology must not have already been established in the literature or with preliminary data. Applications that are focused on technology development to address specific biological questions and/or include unpublished or published data that provide proof of concept are not responsive to this NOFO and will be administratively withdrawn without review.

Funding Opportunity Goal(s)

The National Institute of General Medical Sciences (NIGMS) supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. NIGMS also supports research in specific clinical areas that affect multiple organ systems: anesthesiology and peri-operative pain; clinical pharmacology ​common to multiple drugs and treatments; and injury, critical illness, sepsis, and wound healing.​ NIGMS-funded scientists investigate how living systems work at a range of levels—from molecules and cells to tissues and organs—in research organisms, humans, and populations. Additionally, to ensure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in supporting the training of the next generation of scientists, enhancing the diversity of the scientific workforce, and developing research capacity throughout the country.

Upcoming Due Dates: Feb 16, 2025; June 16, 2025; Oct 16, 2025

Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15)

Clinical Trial Not Allowed: https://grants.nih.gov/grants/guide/pa-files/PAR-24-152.html

Clinical Trial Required: https://grants.nih.gov/grants/guide/pa-files/PAR-24-214.html

Funding Opportunity Purpose

The purpose of this Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions is to support small scale research grants at institutions that do not receive substantial funding from the NIH, with an emphasis on providing biomedical research experiences primarily for undergraduate students and enhancing the research environment at applicant institutions. 

Application Deadlines: February 25, 2025; June 25, 2025; October 25, 2025

Summer Research Education Experience Program (R25 Clinical Trial Not Allowed)

https://grants.nih.gov/grants/guide/pa-files/PAR-24-204.html

Funding Opportunity Purpose

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH.  The overarching goal of this R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nation’s biomedical, behavioral and clinical research needs.

To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on:

Research Experiences for high school students, undergraduate students, and/or high school science teachers during the summer academic break. 

Application Deadlines: March 18, 2025; March 17, 2026; March 17, 2027

NIH Support for Research Excellence (SuRE) Award (R16 - Clinical Trial Not Allowed)

https://grants.nih.gov/grants/guide/pa-files/PAR-24-144.html

Funding Opportunity Purpose:

The SuRE program supports research capacity building at eligible higher education institutions by funding investigator-initiated biomedical research in basic, social, clinical, behavioral, or translational science that falls in the mission areas of the NIH. 

The purpose of SuRE awards is to provide research grant support for faculty investigators at resource-limited institutions who are not currently funded by any NIH Research Project Grants (RPGs) with the exception of SuRE or SuRE-First awards, to furnish students with high-quality undergraduate and/or graduate research experiences and to enhance the institutional scientific research culture.  

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation.  Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

Application Deadline: May 28, 2025

NIH Support for Research Excellence - First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed)

https://grants.nih.gov/grants/guide/pa-files/PAR-24-145.html

Funding Opportunity Purpose:

The SuRE program supports research capacity building at eligible higher education institutions through funding investigator-initiated biomedical research in basic, social, clinical, behavioral, or translational science that falls in the mission areas of the NIH. 

The purpose of SuRE-First awards is to provide research grant support for faculty investigators who have not had prior independent external research grants, to furnish students with high-quality undergraduate and/or graduate research experiences and to enhance the institutional scientific research culture.

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

Application Deadline: May 28, 2025

NSF Faculty Early Career Development Program (CAREER)

https://new.nsf.gov/funding/opportunities/faculty-early-career-development-program-career?utm_medium=email&utm_source=govdelivery

Synopsis of Program:

CAREER: The Faculty Early Career Development (CAREER) Program is a Foundation-wide activity that offers the National Science Foundation's most prestigious awards in support of early-career faculty who have the potential to serve as academic role models in research and education and to lead advances in the mission of their department or organization. Activities pursued by early-career faculty should build a firm foundation for a lifetime of leadership in integrating education and research. NSF encourages submission of CAREER proposals from early-career faculty at all CAREER-eligible organizations and especially encourages women, members of underrepresented minority groups, and persons with disabilities to apply.

Program Description:

This premier program emphasizes the importance the Foundation places on the early development of academic careers dedicated to stimulating the discovery process in which the excitement of research is enhanced by inspired teaching, enthusiastic learning, and disseminating new knowledge. Effective integration of research and education generates a synergy in which the process of discovery stimulates learning, and assures that the findings and methods of research and education are quickly and effectively communicated in a broader context and to a large audience. The CAREER program embodies NSF’s commitment to encourage faculty and academic institutions to value and support the integration of research and education. Successful Principal Investigators will propose creative, effective research and education plans, developed within the context of the mission, goals, and resources of their organizations, while building a firm foundation for a lifetime of contributions to research, education, and their integration. 

Integration of Research and Education - All CAREER proposals should describe an integrated path that will lead to a successful career as an outstanding researcher and educator. NSF recognizes that there is no single approach to an integrated research and education plan, but encourages all applicants to think creatively about the reciprocal relationship between the proposed research and education activities and how they may inform each other in their career development as both outstanding researchers and educators. These plans should reflect the proposer's own disciplinary and educational interests and goals, as well as the needs and context of his or her organization. Because there may be different expectations within different disciplinary fields and/or different organizations, a wide range of research and education activities may be appropriate for the CAREER program. In addition, NSF recognizes that some investigators, given their individual disciplinary and career interests, may wish to pursue an additional activity such as entrepreneurship, industry partnerships, or policy that enhances their research and education plans. Proposers are encouraged to communicate with the CAREER contact or cognizant Program Officer in the Division closest to their area of research to discuss the expectations and approaches that are most appropriate for that area (see https://www.nsf.gov/crssprgm/career/contacts.jsp for a list of CAREER contacts by division).

Application Deadline: July 23, 2025

NSF 24-590: Engineering Research Initiation (ERI)

https://new.nsf.gov/funding/opportunities/eri-engineering-research-initiation/nsf24-590/solicitation

Synopsis of Program:

The NSF Directorate for Engineering (ENG) seeks to build engineering research capacity across the nation by investing in new academic investigators who have yet to receive sufficient research funding from Federal Agencies. The Engineering Research Initiation (ERI) program will support new investigators as they initiate their research programs and advance in their careers as researchers, educators, and innovators. This funding opportunity aims to broaden the base of investigators involved in engineering research and therefore is limited to investigators that are not affiliated with "very high research activity" R1 institutions (according to the Carnegie Classification https://carnegieclassifications.iu.edu/).

At the time of the proposal submission deadline, the PI may not have been a PI or Co-PI on any current or prior awarded NSF research grant (including subaward) or have had research support from any other Federal Agency (within the United States or abroad) totaling $200,000 or more within the past five (5) calendar years from the proposal submission deadline date, with a few exceptions (see link above).

Application Deadline: September 16, 2025

B-INSPIRE: Research on Behavioral Interventions that Promote Careers in the Biomedical Research Enterprise (R01 - Clinical Trial Not Allowed)

https://grants.nih.gov/grants/guide/pa-files/PAR-24-230.html

Funding Opportunity Purpose

The B-INSPIRE: Research on Behavioral INterventionS that Promote Careers In the Biomedical Research Enterprise Notice of Funding Opportunity (NOFO) encourages applications that propose research designed to conduct studies of behavioral interventions to enhance research-oriented individuals' interest, motivation, persistence and preparedness for careers in the biomedical research workforce. Applications that propose conducting secondary data analysis of rigorous interventions, leveraging existing intervention cohorts, using new or advanced methods of analysis of rigorous intervention datasets, or general novel combinations and integration of rigorous intervention datasets for analysis, are also encouraged. Funded projects are expected to produce research findings that will guide the implementation of behavioral interventions in a variety of academic settings and career levels to enhance the diversity of the biomedical research workforce.

Application Deadline: Oct 15, 2025; Oct 14, 2026

Designing Synthetic Cells Beyond the Bounds of Evolution (Designer Cells)

NSF 24-505

Synopsis of Program:

Because of recent technological advances in synthetic biology and bioengineering, researchers are now able to tailor cells and cell-like systems for a variety of basic and applied research purposes. The goal of this solicitation is to support research that (1) develops cell-like systems to identify the minimal requirements for the processes of life, (2) designs synthetically-modified cells to address fundamental questions in the evolution of life or to explore biological diversity beyond that which currently exists in nature, and (3) leverages basic research in cell design to build novel synthetic cell-like systems and cells for innovative biotechnology applications.

Highest funding priority is given to proposals that have outstanding intellectual merit and broader impacts, while proposals with weaknesses in either category (or those that are perceived as likely to have an incremental impact) will not be competitive. Proposals submitted to this solicitation should address social, ethical, and safety issues associated with designing and building synthetically modified cells as an integrated component of the project.

Application Deadline: Feb 1, 2026

Research on Diet-Related Health Data Access Awards

https://www.rwjf.org/en/grants/active-funding-opportunities/2024/research-on-diet-related-health-data-access-awards.html

Program Description:

RWJF, in collaboration with Komodo Health and Mathematica, has launched the Diet-Related Health (DRH) Research Program that will fund innovative studies to explore the impact of diet-related diseases across the country. DRH will provide eight grantees free access to Komodo’s Healthcare Map, which captures real-world patient data. The data will allow researchers to explore the impact of diet on health, improve treatment, and reduce barriers to treatment.

Application Deadline: Feb 21, 2024

RWJF is holding a webinar on Jan 22 from 1-2 pm to provide more information on the program and the data that will be available to awardees. You can register for the webinar here.

The Hannah H Gray Fellows Program from Howard Hughes Medical Institute

https://www.hhmi.org/programs/hanna-h-gray-fellows

Program Description:

The Hanna H. Gray Fellows program seeks to increase diversity in the professoriate by supporting early career researchers who show exceptional promise of becoming academic scientists, which includes the potential to build and contribute to an equitable and inclusive scientific culture. The program targets early career scientists who have fewer than 24 months of postdoctoral research experience by the application due date (2/28/24) with up to $1.5M in funding. For more information, please contact Katie Mackey in RIT Foundation Relations.

Application Deadline: February 28, 2024

NIH U01 Transformative Research to Address Health Disparities and Advance Health Equity

https://grants.nih.gov/grants/guide/rfa-files/RFA-NR-24-004.html

Program Description:

The Transformative Research to Address Health Disparities and Advance Health Equity initiative is soliciting applications to support unusually innovative intervention research addressing social determinants of health (SDOH) which, if successful, would have a major impact on preventing, reducing, or eliminating health disparities and advancing health equity. Projects should clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact on advancing NIH’s commitment to addressing SDOH to accelerate progress in improving health for all. Preliminary data are not required for this initiative.

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn.

Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

Application Deadline: March 22, 2024
Letter of Intent Deadline (encouraged, but not required): February 22, 2024

NIH Novel Approaches to Support Therapeutic Development in Ultra-Rare Cancers (U01)

https://grants.nih.gov/grants/guide/rfa-files/RFA-FD-24-038.html

Funding Opportunity Purpose:

The purpose of this NOFO is to encourage new approaches to support therapeutic development in ultra-rare pediatric and adult cancers, including molecularly-defined subsets of more common cancers. The purpose of this NOFO is to fund research to develop approaches to support drug development in ultra-rare pediatric and adult cancers, including molecularly-defined subsets of more common cancers. The NOFO focuses on supporting studies to improve therapeutic development in ultra-rare cancers with high unmet medical need where there is little economic incentive for commercial entities to conduct the research.

The primary focus of this NOFO is to support research that incorporates new approaches that could be either be applied to facilitate the development of new drugs for the treatment of ultra-rare cancers in general, or one or more specific ultra-rare cancers, including but not necessarily limited to the examples below.

1. Studies to investigate the natural history of ultra-rare cancers. This work could involve analyses of registries and/or other real world data sources
2. Innovative approaches to identify new biologically-driven opportunities for clinical development of previously approved drugs or biologics (hereafter referred to as drugs), including drugs for which development has been discontinued, in ultra-rare cancers.
3. Research to exhaustively characterize the plasma-membrane protein expression (surfaceome) of an ultra-rare cancer and the presumed healthy tissue of origin, as well as the resident-tissue stem cells, by single-cell transcriptomics and proteomics. These studies, and available correlative database analyses, should be designed to identify possible combinatorial signatures of plasma membrane proteins unique to the ultra-rare tumor
4. Research to develop novel approaches to preserve the availability of drugs for which commercial developers have discontinued adult development that have strong potential in ultra-rare cancers but lack financial incentives for commercial development

Direct funding of interventional trials is outside the scope of this NOFO. In addition, studies with a primary goal of developing a specific therapeutic product will not be supported.

Application Deadline: April 5, 2024

a2Pilot Awards

https://www.a2collective.ai/pilotawards?is=6591d298a09e0ae892cedb0c

Funding purpose:

To improve the health and quality of life for older adults, including those with dementia and their caregivers. Each year, research collaboratories at Johns Hopkins (JH AITC), UMass Amherst (MassAITC), and UPenn (PennAITech) provide zero equity funding of up to $200k to 25+ academics/startups for 12-month pilot projects. These projects focus on the development, adaptation, and feasibility testing of novel AI-driven technologies in clinical and real-world settings.

Application deadline: April 30, 2024

NIH Use of Digital Health Technologies in Clinical Investigations to Support Drug and Biological Product Development (U01) Clinical Trials Optional

https://grants.nih.gov/grants/guide/rfa-files/RFA-FD-24-037.html

Funding purpose:

The purpose of this notice of funding opportunity (NOFO) is to address topics related to the use of digital health technologies (DHTs) for remote data acquisition in clinical investigations to support drug development.

Application deadline: May 20, 2024

AHRQ Health Services Research Projects (R01)

https://grants.nih.gov/grants/guide/pa-files/PA-24-154.html

Funding Opportunity Purpose:

The purpose of this Notice of Funding Opportunity (NOFO) is to seek health services research grant applications focused on AHRQ research priorities, including improving healthcare quality and patient safety, improving healthcare delivery and practice improvement, and enhancing whole-person healthcare delivery. AHRQ supports research in all healthcare settings, including the hospital, long-term care, ambulatory care, home healthcare, pharmacy, and care transitions between settings. Research may involve many partners and other groups, including patients, families, clinicians, non-clinical healthcare staff, policymakers, payers, healthcare organizations, providers and accreditors, local and State governments, the Federal Government, and others. 

Application Deadline: June 5, 2024

NIH Leveraging Data at Scale to Understand Natural Product Impacts on Whole Person Health (R01 Clinical Trial Not Allowed)

https://grants.nih.gov/grants/guide/rfa-files/RFA-AT-24-008.html

Funding purpose:

This notice of funding opportunity (NOFO) will support development, adaptation, and/or applications of computational tools to aggregate and analyze orthogonal chemical and/or biological data sets related to natural products with the aim of generating novel testable hypotheses regarding their biological activity and role in the context of whole person health research.  Projects must leverage and merge multiple compatible or interoperable sources and/or types of data.  Use of artificial intelligence and machine learning approaches is encouraged. This NOFO is part of the Consortium Advancing Research on Botanicals and Other Natural Products (CARBON) Program. Other components of this Program include the Botanical Dietary Supplements Translational Research Teams (RM1) and RFA-AT-24-007 Limited Competition: Research Resource for Natural Product Nuclear Magnetic Resonance Data (R24).

Letter of Intent deadline (not required): May 28, 2024

Application deadline: June 28, 2024

NIH Director’s New Innovator Award Program (DP2 Clinical Trial Optional)

https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-24-003.html

Funding Opportunity Purpose

The NIH Director’s New Innovator Award Program supports early stage investigators of exceptional creativity who propose bold and highly innovative research projects with the potential to produce a major impact on broad, important areas relevant to the mission of NIH. For the program to support the best possible researchers and research, applications are sought which reflect the full diversity of the research workforce. To support innovative and novel research across the vast NIH mission, individuals from diverse backgrounds (including those from underrepresented groups; see Notice of NIH’s Interest in Diversity) and from the full spectrum of eligible institutions in all geographic locations are encouraged to apply to this Notice of Funding Opportunity. Applications in all topics relevant to the broad mission of NIH are welcome, including, but not limited to, behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. The NIH Director's New Innovator Award Program complements other ongoing efforts by NIH and its Institutes and Centers to fund early stage investigators. The NIH Director’s New Innovator Award Program is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund.

Application Deadline: August 19, 2024

*This award is for early-stage investigators only

NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional)

https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-24-004.html

Funding Opportunity Purpose

The NIH Director’s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. To support innovative and novel research across the vast NIH mission, individuals from diverse backgrounds (including those from underrepresented groups; see Notice of NIH’s Interest in Diversity) and from the full spectrum of eligible institutions in all geographic locations are encouraged to apply to this Notice of Funding Opportunity. Applications in all topics relevant to the broad mission of NIH are welcome in all topic areas relevant to the broad mission of NIH, including, but not limited to, behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director’s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund.

Application Deadline: September 3, 2024

NIH Director’s Pioneer Award Program (DP1 Clinical Trial Optional)

https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-24-002.html 

Funding Opportunity Purpose

The NIH Director’s Pioneer Award Program supports individual scientists of exceptional creativity who propose bold and highly innovative research projects with the potential to produce a major impact on broad, important areas relevant to the mission of NIH. To be considered pioneering, the proposed research must reflect substantially different scientific directions from those already being pursued in the investigator’s research program or elsewhere. To support innovative and novel research across the vast NIH mission, individuals from diverse backgrounds (including those from underrepresented groups; see Notice of NIH’s Interest in Diversity) and from the full spectrum of eligible institutions in all geographic locations are encouraged to apply. Applications in all topics relevant to the broad mission of NIH are welcome, including, but not limited to, topics in the behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. The NIH Director’s Pioneer Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund.

Application Deadline: September 9, 2024

NSF Emerging Frontiers in Research and Innovation (EFRI): Biocomputing through Engineering Organoid Intelligence

https://new.nsf.gov/funding/opportunities/emerging-frontiers-research-innovation-efri?utm_medium=email&utm_source=govdeliver

Synopsis of Program:

The Emerging Frontiers in Research and Innovation (EFRI) program of the NSF Directorate for Engineering (ENG) serves a critical role in helping ENG focus on important emerging areas in a timely manner. The EFRI Biocomputing through EnGINeering Organoid Intelligence (BEGIN OI) solicitation supports foundational and transformative research to advance the design, engineering, and fabrication of organoid systems that are capable of processing information dynamically while interfacing with non-living systems.

This solicitation will be coordinated with the Directorate for Biological Sciences (BIO), the Directorate for Computer and Information Science and Engineering (CISE), the Directorate for Mathematical and Physical Sciences, and the Directorate for Social, Behavioral, and Economic Sciences (SBE).

The EFRI program seeks proposals with potentially transformative ideas that represent an opportunity for a significant shift in fundamental engineering knowledge with strong potential for long term impact on national needs or a grand challenge. The proposals must also meet the detailed requirements delineated in this solicitation.

Letter of Intent Deadline: Sept 12, 2024

Application Deadline: Dec 12, 2024

UKRI/BBSRC- NSF/BIO Lead Agency Opportunity in Biological Informatics, Systems Understanding of Host-Microbe Interactions, Synthetic Cells and Cellular Systems, and Synthetic Microbial Communities

https://www.nsf.gov/pubs/2024/nsf24112/nsf24112.jsp?WT.mc_ev=click&WT.mc_id=&utm_medium=email&utm_source=govdelivery

Through this Dear Colleague Letter (DCL), the NSF Directorate for Biological Sciences (NSF/BIO) and the UKRI Biotechnology and Biological Sciences Research Council (BBSRC) are pleased to announce 2024/2025 topical areas associated with this Lead Agency Opportunity.

The goal of this activity is to promote transatlantic collaborative research by reducing some of the barriers that researchers may encounter. The NSF/BIO-UKRI/BBSRC Lead Agency Opportunity allows U.S. and U.K. researchers to submit a single joint proposal that will undergo a single review process. This document provides guidelines for the preparation, submission, review, and award of joint NSF/BIO-UKRI/BBSRC proposals. 

Research Themes for 2024/2025: Biological Informatics, Understanding host-microbe interactions, Synthetic Cells and Cellular Systems, Synthetic Microbial Communities

Deadline for Expression of Interest (EOI): October 31, 2024

Deadline for Full Proposal (for NSF/BIO): February 28, 2025